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The Valley of Death and how to traverse it

Member News
The views expressed in this Member News article are the author's own and do not necessarily represent those of Agri-TechE.

Do you have ambitions to create or develop a novel, groundbreaking technology? If so, it is highly likely you will need significant investment and encounter the Valley of Death. The Valley of Death is the phase between starting the business and generating the first revenue or return, a gap that requires investment to bridge. To attract investors, however, you need to demonstrate that you’re a good investment.  

Raising investment is a competition

In the early stages of attracting venture capital, there is a lot of competition. Attempting to procure financing takes a lot of time and energy. To maximize your chances of success, it is important that you have a good plan of action, sufficient data to present, and a strong executive team. To deliver the right proposition to the right investor, it is important to understand the dynamics of venture capital.

Sufficient growth potential

Being an interesting investment opportunity also requires the company to have sufficient growth potential of at least a 10x investment multiple. The phase and the proposition must match the fund criteria, such as the company having good Intellectual Property, a strong management team, and an investment demand which falls within the investment range and timing of the targeted investor. Hence, the attractive companies are usually at a somewhat later stage and thus have more to show the investor. To get there as a start-up, however, you obviously need funding and so there might be a misalignment between the ideal moment for the investor or for you as a start-up.

Preparation is key

Unfortunately, at F.INSTITUTE we regularly see companies enter into discussions with parties for the investment or negotiation of licenses without being properly prepared. So how do you prepare? Here are some tips and tricks:

  1. It can be difficult to be dependent on external financing. I would therefore recommend thinking about a mix of different dilutive and non-dilutive financial sources – to avoid becoming dependent on just one.
  2. Be flexible and stay open-minded. Bring in the right expertise to avoid possible delays. That also means being open to alternative strategies (Plan B) that you might not have anticipated.
  3. Use all possible means to create the longest runway, during which you need to focus on achieving important milestones such as proof of concept, first in human, and CE marking in the case of MedTech companies.
  4. It’s important to monitor your cash flow at all times. Make sure you have the proper tools to provide you with real-time insight so you are not taken by surprise and run out of money too soon. Proper cash flow management also helps to prepare you for the next round of capital investment on time.
  5. Last but not least, seek professional counsel as early as possible. It is a tough journey and you may encounter some unexpected challenges along the way. With the proper advice, you will create a more in-depth view of your chances of success, lead times, and other important aspects when raising funds. This will make you better prepared to face the Valley of Death and survive it!

KISS announces exciting merger with Isle Interactive

Member News
The views expressed in this Member News article are the author's own and do not necessarily represent those of Agri-TechE.

KISS Communications announced today its merger with digital agency Isle Interactive, adding significant resources and strengthening its position as a leading creative agency.

The merger gives the award-winning agency the foundation to achieve its ambitious growth plans and broaden and strengthen its offer across marketing and brand strategy, campaign development, in-market activation and digital delivery – with creativity at its heart.

The newly combined team will add even more value and expertise to the agency’s blue-chip national and international clients operating within the science, education, agri and tech sectors.

KISS MD Sarah Reakes said, “This is a game changer for the future of the business. Isle brings a wealth of digital knowledge to an already strong team, we have similar ambitions for growth and our teams’ skill sets are incredibly complementary, so it makes perfect sense to join forces.

“We’ve already worked together over the years and there has been a lot of mutual admiration. We know and respect each other’s different strengths, and we look for similar things in our work. In an industry that’s so highly competitive it’s moves like this which enable us to stay ahead of the game and deliver only the very best creative work for our clients,” added Sarah, who remains Managing Director of the expanded agency.

The KISS name stays, and the Isle team will all transition and join their colleagues at the company’s HQ at The Pitt Building in the heart of Cambridge. The merger creates a team of over 30 staff servicing clients which include, Bayer Crop ScienceBacsBedrock LearningMarshall Group, Taylor & Francis, Virgin Limited Edition, Cambridge Education Group, CATS Global Schools and Cambridge Network.

Isle co-founder Richard Copping, who becomes Operations Director, and will lead the project management team, added, “We’re thrilled to be able to combine our talent and expertise as one integrated agency. We can handle ever more complex digital projects, and with the strategic and creative power of the KISS people, this feels like a strong and unbeatable proposition.”

As part of the merger a new leadership structure sees CEO Simon Fryer take on the newly established role of Chairman. The Senior Leadership Team is further boosted as Isle founder Iwan Moore becomes Technical Director, while Sue Cartwright has been promoted to Deputy Managing Director to complete the change.

Norwich Research Park launches strategy for new business investment

Member News
The views expressed in this Member News article are the author's own and do not necessarily represent those of Agri-TechE.


The Enterprise Strategy from Anglia Innovation Partnership LLP will kickstart investment into new businesses at Norwich Research Park.

Anglia Innovation Partnership LLP, the organisation that manages Norwich Research Park, has launched its Enterprise Strategy to kickstart investment into new businesses at the Park.

Its aim is two-fold: to encourage those with a potential idea for a business – be they entrepreneurs or people studying or working at the Park – to come forward for support. It will also highlight to investors – whether venture capital companies or high net worth individuals – the potential return on investment the Park offers spin-outs, spin-ins and start-ups.

The Enterprise Strategy was launched last month with two events run specifically for new businesses and investors. Both events, led by new CEO of Anglia Innovation Partnership LLP Roz Bird, attracted large audiences and a lot of interest.

A pre-seed enterprise fund, set up as a partnership between Norwich Research Park and the John Innes Foundation, is one of the key strands of the strategy to encourage business start-ups. Successful applicants can receive up to £25,000 from the fund to develop business ideas.

This funding is available to budding entrepreneurs studying at the University of East Anglia (UEA) or working at one of the four world-leading research institutes: Earlham Institute, Quadram Institute, John Innes Centre and The Sainsbury Laboratory, as well as the Norfolk and Norwich University Hospital.

Once a company has been set up, it can then apply for the next stage of investment – a seed fund run by QUBIS, the commercial arm of the Queen’s University of Belfast, in partnership with Sapphire Capital. Through continuing support from QUBIS, the aim is for the businesses to eventually attract investment from local angel investors and high net worth individuals.

Roz said: “Investors will be interested in funding start-ups through the Enterprise Strategy because of all the untapped potential that exists with the wealth of world-leading researchers working here at the Park.

“QUBIS can work through all the ideas, identify the ones that have real potential and then provide support to those who are genuinely interested in getting things to the stage where they have a compelling proposition to present to investors.
“That means by the time private investors get involved, they’ll see that by going through a robust process the companies will be in good shape to be evaluated and hopefully attract funding.”

Anne Dornan, innovation partnerships manager at QUBIS, said: “A lot of these companies stay and grow within the place where they were created because there’s that stickiness, there’s that reliance on the wider environment and infrastructure, with the superb world-class facilities that are here.”

Norwich Research Park is home to a number of high-growth businesses that have raised significant investment, increased their workforces and are rapidly building customer bases.

In 2020, Tropic Biosciences, which is working on developing new disease-resistant variants of banana and coffee plants using gene editing techniques, raised $28.5m (£22.7m) and has grown its workforce to 120. Colorifix, a company that is pioneering a new sustainable dyeing process for the fashion industry, raised $22.6m (£18m) in 2022 and is already working with retail giant H&M. And there are many more companies such as Leaf Expression Systems, Iceni Glyoscience, Coral Eyewear and iBoxit that are emerging as high-growth businesses.

Companies that have successfully established themselves at Norwich Research Park can gear up for the next phase of expansion. A number of new buildings are planned, which will offer incubation and accelerator facilities for new businesses. There are also 52 hectares of land ready for development, which should appeal to investors or company owners looking to relocate.

Norwich Research Park’s relationship with the landowners, South Norfolk Council and New Anglia LEP, is another added benefit when it comes to things like planning and developing the infrastructure needed to support business growth and relocation.

Roz added: “I took the post of CEO at Anglia Innovation Partnership LLP because Norwich Research Park has so many of the ingredients needed for future success. Each of the organisations onsite has an amazing track record and reputation and can help to solve some of society’s biggest challenges.

“The team will work with these great institutions and our partners to help maximise the potential of their research and development activity by creating a great place to start and grow a business. Our Enterprise Strategy is a key element of that success – ensuring there is a process embedded in Norwich Research Park’s ecosystem to identify, nurture and support start-up businesses.”

Farm Safety: 5 tips to improve safety on farm with fieldmargin

Member News
The views expressed in this Member News article are the author's own and do not necessarily represent those of Agri-TechE.

Unfortunately farming has a poor safety record when compared to other sectors. Together we need to work on raising awareness and reducing the risk of harm.

You can never say enough how much these accidents impact family and friends. Last year, Sean Arians, a northwestern Illinois farmer and grower direct business lead for Advanced Agrilytics, talks about the loss of his friend. His letter to his friend is also a call to fellow farmers to not forget the lessons learned,  a plea to all farmers to slow down and farm safe. 

Farm safety is a full-time job. It is often brought up in feedback with our team and it is a priorty on of a lot of our users.

“We are acutely aware of the risks and hazards associated with agriculture. As a contractor, we need to carry out risk assessments several times a day. We have already seen the benefits of documenting & sharing risks on farms whilst also being able to see where everyone is working.”Rob Boole

With this in mind here are our 5 tips for ways that fieldmargin can be used as a digital tool to help yourself and other people on the farm stay safe.

  1. Map farm hazards

Incidents with overhead power lines made up 10% of farm fatalities in the past year. Make sure that everyone on your farm is aware of hazards such as power lines and ditches/dykes so that these can be avoided. 

  1. ⚠️ Add hazards to your digital farm map on fieldmargin as features  (read more here)
  2. ?‍? Invite everyone who works on your farm to access it so that they know where they are. 
  3. ⛑You can also add important resources that might be needed in case of an emergency such as fire extinguishers and first aid kits.

2. Let your team know where you are

If you have an accident or breakdown and need assistance the last thing you want is to have to spend time trying to explain where you are so that help can find you. 

Team Radar lets you share where you are using the GPS on your mobile phone so that your location is updated whenever you are connected to the internet and open the fieldmargin app, allowing everyone on your farm to see where you are and find you if there is a problem. Learn how to set it up here.

Share your location with Team Radar
  1.  Identify risks and work out how they can be eliminated

Working on a farm every day it is easy to overlook risks or see them and think “I’ll deal with them later”.  You can make the job of identifying risks on the farm less overwhelming by making it something that everyone working on the farm takes responsibility for.  

Every time someone spots a problem that needs fixing such as obstructions in work areas, damaged flooring or walkways they can make a note in fieldmargin with its location and include pictures to make it clear what the issue is.  You can go through these on a regular basis to see what needs to be done to fix them and make tasks to remind you to get the work done. 

  1. Stay in touch

Most farmers spend a lot of their time working alone, often in isolated areas. 

Let people know where you are going to be working and how long you expect to be, particularly if you are going to do something you know if potentially risky. 

In fieldmargin you can use comments on notes or jobs to quickly give your team a heads up on work you’re planning to do so that all of your team can see and check up if you’re not back in the time you plan.

  1. Record your risk assessments alongside your work

Keeping an eye on risks and how to mitigate them as you go is a good habit to be in. Particularly when going out to new farms as a contractor you may be dealing with sites that you are unfamiliar with it is good to survey the site for risks and make a note of what you found. 

You can use comments to quickly log your findings against the job or task that you are completing so that it becomes part of the team’s workflow. You can also attach files or take pictures of paperwork to store additional risk assessments with the record, for example COSHH risk assessments.

How are you working to improve Health and Safety on your farm? Let us know in the comments below

Learn more about farm health and safety risks and how to improve safety on farm on the HSE website here.

See how fieldmargin Pro can help on your farm with a free 14-day trial of Pro. No credit card required.

The story of Stable from a fintech farmer

Member News
The views expressed in this Member News article are the author's own and do not necessarily represent those of Agri-TechE.

Today is a thrilling day for Stable as we announce a $60m Series B led by the amazing Vishal Lugani at Acrew, as well as our friends at NotionGreycroftContinental GrainAlumni VenturesSyngentaGaingels and many others. I’m hugely grateful for their unfailing support and belief in our team as we continue our extraordinary journey to help millions of businesses around the world protect themselves from volatile commodity prices.

This milestone marks a new chapter in our work to build the ‘Home of Hedging’. We’re a young company, but we’ve already been through a huge amount together as we continue to push hard and try to build something truly extraordinary.

Being a solo founder doesn’t give you much time to pause and think about what we’ve done as a team and the inevitable highs and lows along the way, so I thought I’d share some of that story (before I forget it or block it out!) with the hope that it might give someone else the confidence to take a chance on their own idea and back themselves to build it.

The first thing to admit right off the bat was that the early probabilities of Stable making it to Series B were not great. I knew nothing about commodity markets or insurance, and this was going to be a data science led company, run by someone who just scraped a B in Math. One of the only things I took away from my school days was a sense that every time I asked a question where I was sure everyone else knew the answer, it was amazing how many people then joined in and said they were also struggling to follow along.

As it turned out, the willingness to ask ‘why’ over and over is an essential (if slightly annoying) skill to dig out commercial opportunities that have been fossilized in layers of industry bedrock. As an entrepreneur, it often pays to start digging in sectors that assume significant amounts of knowledge, favor tradition over innovation, lack the power of diversity and mildly resent the emergence of technology in their working lives. The agricultural commodity industry ticks most of those boxes, and yet by any measure it’s a $8trillion dollar industry that’s responsible for feeding a growing global population with a smaller environmental footprint.

I used to walk past the CME building in Chicago on my way to work each morning and it always intrigued me to think what happened inside those four walls.

Growing up on a farm, I was naturally interested in agricultural markets, but anytime I read about hedging commodity prices I got an overwhelming sense that this was a financial world not meant for the likes of a farmer’s son like me.

That changed in 2016, as the price of milk in Europe dropped and thousands of family farms like my dad’s faced a very uncertain future as they became increasingly exposed to global markets. These were hard working family businesses that were periodically exposed to global market events that they couldn’t possibly control. It seemed from the outside that an industry that started in Chicago in the 1840’s to simply manage price risk for sellers and buyers of corn and wheat had forgotten its own roots and lost sight of its own purpose in the world.

Hedging is hard. It can be complex, risky, imprecise, illiquid and opaque. Yet when thought of as price insurance it clears a pathway for a far wider range of businesses to think about its value and application to their own business. If it could be made simple, precise and accessible then the potential benefits for the world’s most important industry would be huge. I became determined to try and find a way to reimagine risk management, so hedging could become a catalyst for change by providing businesses of every size and sector the confidence to invest in their future. It goes without saying that when it comes to food, it really is about all our futures.

So the massive problem that needed solving was becoming clearer, but taking your first tentative steps to disrupt an entire category of finance is always going to throw up some curveballs.

The saving grace in these situations is that true outsiders have a seriously unfair advantage. It’s easy to underestimate how valuable a fresh pair of eyes can be in an industry that they haven’t been involved in for the last 20 years. Stable exists at the intersection of derivatives and insurance and a long career in either one of these fields could have easily created an innovation echo chamber within just one sector. If we were going to create a global price risk marketplace, for example, we needed to reach across two sectors while delivering a product that focused obsessively on just one priority — our customers.

In 2016, I was fortunate enough to be awarded a Nuffield Scholarship. This enabled me to travel the world and ask hundreds of agri-food businesses how they thought about hedging and what changes would make it work better for their business.

At this stage I was totally focused on helping farmers protect themselves from the risk of a price fall.

As these trips continued, I increasingly met cooperatives and even food processors who were interested in what we were discussing. I was thrilled to meet these large food manufacturing companies, as I thought it would be useful to learn from hedging experts with real commercial experience.

In one meeting with a $750m dairy company I was told very clearly that they don’t hedge their input costs and never have. At the end of the meeting, we walked out towards the lift and I casually asked the CEO why they don’t hedge their input costs. His casual answer changed everything for me at Stable: ‘We don’t hedge because we don’t really understand how it works, so it’s easier to do nothing.”

This was like an bomb going off in my head as I realized at that moment that the opportunity to simplify hedging was far bigger than I had thought and that Stable could play a much bigger role in the agri-food industry by helping both producers and consumers.

While an unexpectedly large addressable market was a great distraction, there was an elephant in the room that could no longer be ignored. If we were going to create the home of hedging, we’d need to help clients manage the risk of untraded commodities in addition to the actively traded commodities found on the likes of the CME and EEX.

That meant the ability to price untraded risk was essential, and that was clearly a massive challenge. The price of a financial option uses a formula called Black Scholes Merton and to work properly, that formula requires the implied volatility that you can only get from a traded market. For Stable to succeed, we needed to redesign that famous formula and use machine learning to simulate the implied volatility surface so we could price the risk in a consistent and measurable way.

With no money to help solve a big issue that simply had to be overcome, the only option I had was to start looking online for academics who were interested in price risk transfer mechanisms and the actuarial science around commodity price risk.

After weeks of searching papers that only occasionally made any sense, I could see a few well known academics in the US and UK were clearly leading the field in this area. With nothing to lose, I fired off a few speculative emails and hoped they might spark some interest. One was to Harvard University’s Professor Yiling Chen and one was to Liverpool University’s Professor Hirbod Assa.

To my surprise and delight, they both responded and were incredibly generous with their time. We discussed the challenge of pricing risk, but also a simple idea I’d had that might help us manage the future portfolio that was inspired by a very old fashioned farming phrase, ‘up horn, down corn.’

This olde world phrase is trying to explain the natural diversification of a traditional mixed farm producing multiple commodities in order to protect themselves from price risk. I wanted to explore whether this very traditional concept of hedging risk via simple diversification could be replicated and expanded using very modern data science tools across thousands of commodities in over 50 countries. In effect we wanted to build a portfolio that acted like the world’s biggest and most diverse farm!

The result was one of the most exciting professional periods of my life and I will always be grateful for the incredible academic help we received when the project was really at its lowest ebb in terms of progress.

My biggest takeaway for other founders facing similar hard yards was that both of these universities expressed surprise that so few people got in touch and asked them for help! With the extraordinary support of the academic community, the path to pricing the risk became clearer, although it would take another 18 months and the amazing work of a brilliant PhD student called Simon Wang for it to become a reality.

Simon is now our CTO and leads a team of 20+ Quants and data scientists with enormous skill, and together with Rachel and Victor (our Oxford Uni Quants), they hold us accountable to never compromise on our commitment to deploy extraordinary data science.

The unlikely combination of a beef farmer’s son from England and a math genius from China is one that I hope will always remind us as a team to keep pushing hard to seek the amazing alchemy that can happen in genuinely diverse teams.

During this time I was working in an old cow shed on my family farm and using that relative solitude to plan out our next steps and raise a small pre-seed round of capital to enable us to get the licenses we’d need to sell Stable as an insurance product during our soft launch to UK farmers. This successful pilot enabled us to secure the early support of some amazing angel investors, such as Edward Wakefield, Charles Norton Smith, Andrew Petherick, the Mercer family, John de Ramsay and all the team at Cambridge Agritech.

These early first steps simply couldn’t have happened without the help of our friends at the insurers Ascot in London. They had the patience, curiosity and skills to work with a young team of financial engineers and help us establish the framework, validation and commercial skills we needed to operate alongside the best insurers in the world and eventually backed us with our crucial first tranche of risk capital. Andrew Brooks, Mark Pepper, Parth Patel, Rebecca Wilkinson, Ian Thompson and the wider team were and remain outstanding partners who took a big chance on us and proved time and again why they’re so widely recognised in the insurance industry.

Shortly after we launched the pilot — I had a rush of blood to the head and joined Twitter (@fintechfarmer since you asked!) and I think my first ever ‘DM’ was from Matt Jones who suggested we meet up in London. Matt worked for a VC called Anthemis, and shortly after I met the Anthemis crew and the irrepressible Ruth Foxe Blader, Sean Parker et al who became our first institutional investors at a pre-seed stage.

Despite the fact that I think — embarrassingly — I talked about my love of cows in our first meeting, it was clear very quickly that we’d get along and that we shared an illicit fascination for the risk management space. We have been working side by side ever since. After all the work and wrong turns just to get to that point, their uncomplicated belief in not only our potential as a team but also in me personally is impossible to overstate in terms of the confidence it gave us all at that early stage.

It would be fair to say we thought we were about to enjoy a period of plain sailing, but for a group of data scientists this was a terrible forecast to make. During the pilot, we started closely tracking the politics of Brexit and were hoping that this wasn’t going to impact us as a small UK technology company which by that time was also a regulated insurance intermediary. I remember that it seemed impossibly unfair timing, but the eventual vote meant we had to make some really hard choices about how we as a team could hope to scale Stable internationally, as losing the EU financial passport had huge implications in terms of the regulatory costs of selling in Europe.

The models were working, the team was exceptional, we’d been joined by Louise Derbes (who left a senior position at Rabobank to join us) Will Ormerod and Joe Brooker (who joined us from Louis Dreyfus and Platts respectively) and the market was responding well to the innovation we were bringing to the party. Despite this, I knew I had to make a big call that couldn’t be avoided and one that would change Stable forever. London had to become our technology and R&D center, and our sales focus turned west to the US market, where the simpler regulation and a larger market size made more sense financially.

Shortly after making that decision I received an email from a man called Chris Roeder who’d recently left Cargill and had read about what we were building and wanted to join us. I knew within minutes that he had to be on the team, and he joined us as our first US hire. It was one of the single best calls I’ve ever made in my career. Chris led the US sales effort until he was joined by the one and only Tony Ness, his good friend and fellow Cargill alumni, as well as Jim Sullivan from the CME itself. As the team grew, they were joined by Taylor Coughlin from McDonalds, John Stotts from Belevedere, Erick Rodriguez from Yum Brands and Michael Nepveux from AFM and many more.

With Brexit fading in the rear view mirror and a tight team emerging in the US, we gained the confidence to expand beyond Lloyds of London. To be able to truly scale, we wanted to think big from the start and set up our own risk capital operations (rather than a broker/MGA relationship) in order to innovate wherever possible and to remove any unnecessary costs for our clients.

Other than having a few mates who grew up in Bermuda, I knew nothing about the rocky outcrop that I always assumed was in the Caribbean, and I certainly didn’t realize it was a global hub of reinsurance. If this was going to be a potential new home for our risk capital operations, we clearly needed an expert in reinsurance who would relate to our dream to change an industry and who would genuinely understand how we could create a whole new business line for reinsurers. A couple of people I trusted mentioned a lady called Julia Henderson and thought we’d get along. We arranged a call and spoke for hours about what Stable was building and why it mattered.

It was clear in early calls that while we really did get along, it was also clear she thought it was totally mad, but could sense the potential size of the opportunity. She also had a fantastic job on the island and was enormously respected as a fearless innovator in an industry that is still very pale and very male, and I was determined to bring her onto the team. For Julia to join Stable- a startup with no track record — required a huge leap of faith. It took a while, but in 2021 Julia came on board full time, arriving at Stable like a Bermudian hurricane, and she quickly got our risk capital strategy moving and became our own rock at the center of the team. She was instrumental in getting us regulated as an insurer, getting our local office set up and working with the likes of Brad Adderley at Applebys Andrew Hitchings and Mike Pummel at Guy Carpenter and the ever supportive BMA as we now start to build our own fund (most of which gets planned out in her garden!)

Covid arrived at roughly the same time as all of this was going on, but after all we’d been through and with the team we’d built, I knew we’d be ok once we all adjusted to life on Zoom and the inevitable terrible virtual quiz nights. Our sales team did a truly extraordinary job of launching a new product in a new market during lockdown, and I couldn’t believe how quickly they built the pipeline compared to our more cautious European clients.

In less than 9 months we had over 250 of America’s largest food companies in our pipeline, having spent less than $10,000 on marketing. As things have thankfully opened up, that has continued to grow enormously (sadly, so has our marketing budget!) along with our ability to actually meet up with our partners and clients and the phenomenal marketing and platform teams we now have under Caroline and Karan respectively in New York.

Reminding myself of those early days of working with just Simon and Sam, our first developer, in a free and very small office in Liverpool makes me pinch myself as I now watch 60+ people logging into our all-hands calls from our offices in NYC, Chicago, London, Bermuda and Singapore.

It’s easy to say, but I hope that somewhere within this post you get a true sense of why I feel it’s such a privilege to lead this talented team of people from every corner of the world, who have left exceptional careers at insurers, banks, trade houses and hedge funds to join a small startup and try to build something spectacular. That trust in me personally and the product the team has built is really humbling and not something I will ever take for granted as we look forward to the next stage of life at Stable.

Reminiscing like this is of course hugely indulgent at such an early stage, but I simply wanted to put our reality of life at our startup down on paper to see if it could help anyone else that is wondering if they too should take that leap of faith, so they can better understand how a day like today really happens.

It’s not complex and it’s not about having a great idea, it’s just the logical output of what a small group of people can do when they simply refuse to stop solving the next issue in front of them.

That’s as close as I can get to any advice from someone who’s made every mistake in the book.

What’s next for Stable?

The new investment and upcoming launch of our client platform will see Stable go much further and much faster as we work towards becoming the global home of hedging.

We’re investing in new algorithms to price more risk, new products to help clients visualize their exposures, new partnerships with industry leaders, new research, content and sales pods to help more sectors in more countries (next up South America!) and the launch of our new fund in Bermuda with the help of the amazing risk team of Nikki, Will, John, Gill and Patrick.

There is much to do, so we’re hiring across all of our departments. If Stable sounds like the type of place you could help us build something remarkable, then we’d love to hear from you!

After four years of sitting next to the data scientists at Stable, I’m embarrassed to report that my Math hasn’t improved one bit. However, after 20 years of trying hard to build a business like Stable — one that solves a real problem, at scale, and in an industry that matters — I think I’ve finally worked out one small piece of the startup jigsaw.

Math isn’t the thing that makes days like today happen. Investors and partners are awesome, but they alone don’t get you there. My piece of the jigsaw, like all founders, is to hire the likes of Marco, Julia, Caroline, Louise, Karan and Simon and all the other rockstars at Stable and simply give them a stage and the confidence to shine.

FD Roosevelt nailed the role of a founder (and President) when he reminded us of what he brought to the table:

‘I’m not the smartest fellow in the world, but I can sure pick smart colleagues’.

FOLIUM Science achieves major commercial milestone

Member News
The views expressed in this Member News article are the author's own and do not necessarily represent those of Agri-TechE.

Bristol based biotech business FOLIUM Science has completed an important milestone in its commercialisation phase as it continues to develop its ground-breaking technology platform that selectively removes unwanted bacteria from an animal’s gut.

This patented technology, called Guided Biotics®, will remove the need to use antibiotics in farmed animals. In a world where antimicrobial resistance is a global problem, where antibiotics are increasingly ineffective, unacceptable to consumers and restricted in use, FOLIUM Science’s revolutionary biotechnology helps to solve these problems by supporting positive animal nutrition and sustainable animal farming.

In collaboration with a leading multinational animal nutrition partner, FOLIUM Science can now build on promising in-vivo trial work and begin the process of bringing the first product to market.

Using the Guided Biotics® technology, trials in poultry flocks have shown incredibly promising results in reducing Salmonella. Food poisoning continues to be a problem across the world, with salmonellosis cases now increasing in many countries. Non-typhoidal salmonellosis is reported to cause over one million infections, 19,000 hospitalizations and over 400 deaths annually in the US, with some Salmonella strains showing antibiotic resistance.

Salmonella in the gut of a chicken is difficult to control, however unlike the action of antibiotics that will kill the good bacteria in the gut as well as the bad, Guided Biotics® selectively remove only the undesirable bacteria, leaving the beneficial bacteria intact. This supports a positive gut microbiome by allowing these beneficial bacteria to thrive.

Guided Biotics® technology represents a new category in animal feed additives and functional nutrition, that can directly benefit animal well-being by supporting a healthy microbiome.

The development of modelling techniques to quickly assess the effectiveness of new products is an innovative tool that allows the FOLIUM Science team to screen alternatives and identify the versions that are most likely to be successful. This creates an efficient product delivery process that can be taken forward into live trials.

Creating strong and focussed teams in each development area has also proved fruitful where technical specialists and support staff work closely together to share ideas and improve expertise across the business.

The new partnership and investment will enable FOLIUM Science to move to the next stage of commercialisation and not only develop the application of Guided Biotics® technology in poultry but continue the development of future programmes that include applications in cattle, swine and aquaculture. Development platforms in the pipeline also include products to modulate an animal’s microbiome to give the friendly bacteria beneficial advantages over pathogens in the gut.

FOLIUM Science CEO Ed Fuchs says “I am delighted to have achieved this breakthrough which was part of the strategic roadmap created 4 years ago when the business was founded.  Our goals and focus on the Guided Biotic Platform are fully aligned to the multinational partner’s animal nutrition business unit. This validates the market opportunity and unlocks well established capability to deliver Guided Biotic products in market. 

It is a credit to the FOLIUM Science team how they have evolved the Guided Biotic platform to application in the most challenging real-world environment.  We can also celebrate our own expansion of capacity in the move to new laboratory facilities at Science Creates in Bristol.  These facilities enable us to achieve our vision and expand into modulating gut microbiomes to reduce waste and improve productivity.

The founders are also excited to be working on similar technology for food processing, plant health and human dietary requirements.  These applications are a mere walk in the park!”   

The joint development agreement involves an undisclosed sum for a multi-year investment and commercialisation rights to BiomElix One®, a feed additive for poultry and other species that targets all Salmonella serotypes.

The benefits of working with a major multinational with a very strong research ethic  are clear. The collaboration between both teams of scientists on product development alongside shared contacts and expertise will bring advantages to all stakeholders. The manufacturing facilities and regulatory know-how offered by the partnership will also have a significant impact on the speed with which products can be brought to market and facilitate the advancement of new platforms.

The FOLIUM Science team of scientists will continue to operate from the dedicated research base in Bristol UK enabling the business to further expand the capabilities of Guided Biotics® across wide range of pathogenic, wastage and spoilage bacteria.

Breedr launches sheep recording app

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The views expressed in this Member News article are the author's own and do not necessarily represent those of Agri-TechE.

Sheep and beef producers can now record their livestock data in one place, helping to improve farm management, compliance and efficiencies.

Breedr, the precision livestock network, has launched a new sheep element to its free app, meaning producers can record lambing details, weights and medicine usage directly into their phone or tablet.

They can also produce performance reports and trade livestock directly with other farmers, based on lifetime animal data, for fully transparent supply chains.

Pembrokeshire  farmer Steve Prentice helped to develop the sheep app and is impressed by how it helps to improve breeding and management decisions.

“There are a lot of software programs for managing cattle but there are differences in how sheep farmers think and work – the value of cows is significantly more and they don’t have triplets all the time,” he says.

“There are also differences in requirements for pedigree flocks where everything is recorded and the more commercial flocks where individual genetics are less important but overall lambing performance and weight gain are key. Breedr can look at both.”

Steve uploads new lamb data to the app, including dam, sire, date of birth and weight, as well as vaccinations and treatments for coccidiosis, fluke and worms.

Medicine book

“Breedr replaces the Defra medicine book by recording medicines, batch numbers and treatment, for every animal. It also allows us to record the general performance of ewes.”

Once a month he runs all sheep through a race and crush where he scans ear tags and automatically records the animal’s weight. “It is fast and easy, linking the weight to the animal identity without having to do any typing or manually read ear tags.”

Looking ahead, Steve is keen to optimise his flock performance. “With limited land we need to decide which sheep to keep and which to sell based on performance and bloodlines – with the app those decisions are based on data.”

As well as the free sheep app, Breedr has launched a Pro version enabling mixed farmers to record their beef and sheep data in one place.

On top of giving them seamless access to their sheep and beef information and trading platforms, Pro offers advanced reporting of Key Performance Indicators, benchmarking against industry targets and other Breedr farmers, and detailed farm maps to show where different animals are located or grazing.

Vital data

Peter Broad, who farms near Launceston, Cornwall has been using the app to gain a deeper insight into data from both his cattle and sheep enterprises. “I wanted to use as much data as possible – it’s vital to the business.”

Peter runs a flock of 400 commercial Mules and buys in store cattle or calves to finish indoors in February and March. He used the Countryside Productivity Scheme to buy some weigh heads and scales and now tracks daily liveweight gains in the Breedr app.

“The biggest thing is that I’ll be able to predict how many lambs to sell each week and book them in so we’re not keeping them any longer than we need to.”

The app is also useful for capturing the breeding information for each sheep, he adds. “By linking the lambs back to their mothers and capturing all the lambing history we have a clean, easy to access set of records when it comes to replacing some of the older or underperforming ewes.”

UK TECH COMPANY SELECTS MISSOURI AS BASE FOR US OPERATIONS

Member News
The views expressed in this Member News article are the author's own and do not necessarily represent those of Agri-TechE.

Wyld Networks, a tech company that specializes in wireless connectivity for the Internet of Things (IoT), has announced plans to base the company’s USA operations in Missouri. Wyld will use Missouri as their launching point to develop satellite IoT for US agriculture and supply chain sectors.

“We are thrilled to welcome Wyld Networks to Missouri,” Governor Parson said. “It was a privilege to meet with the company during our trade mission to the United Kingdom, and we’re confident Wyld Networks’ strengths in agtech and geospatial technology are a great fit for our state. With continued innovative advances in agriculture, Missouri is supporting high-tech companies as they grow here, creating jobs and making investments that strengthen our economy.”

“Critical to Wyld’s growth strategy is the need to engage with the world’s largest and most influential economy,” said Alastair Williamson, CEO of Wyld Networks. “A base in St Louis is a significant step to realize this ambition.”

The Missouri Department of Agriculture predict agriculture, forestry and related industries in the state are estimated to contribute $93.7 billion economic contribution in 2021. In order to meet the significant challenges of reducing inputs, improving yields, meeting sustainability targets in the sector a massive drive to digitization is seen as essential.

Capturing data from IoT sensors in often remote locations with no cellular coverage and no power source is big part of this challenge. The 100% global satellite IoT coverage that Wyld offers is set to liberate the Internet of Things (IoT) enabling mass digitization and releasing the flow of valuable data.

Wyld is currently deploying a sensor to satellite solution for Bayer in Missouri and have also created a consortium with Eutelsat, Senet and TrakAssure to monitor supply chains with a hybrid terrestrial and satellite IoT solution.

“I had the honor of meeting Wyld Networks when they visited Missouri in 2020 as part of the Agri-TechE mission,” said Alan Gogbashian, UK Consul General to the Midwest. “And that relationship was built throughout the pandemic via Zoom and other means, culminating in additional meetings during the recent mission to the UK by Missouri’s Governor. We are thrilled that this great British company is expanding to the US, and choosing to set up in one of the strongest agritech ecosystems in the USA”

“Following the opportunity to host Wyld Networks, and a delegation of United Kingdom based companies led by Agri-TechE , to St. Louis in February 2020, representatives from World Trade Center St. Louis, Missouri Partnership and 39 North Innovation Community fostered a relationship with Wyld Networks, meeting regularly via Zoom and making important follow up industry and research connections,” said Tim Nowak, Executive Director, World Trade Center St. Louis. “This relationship now culminates in Wyld Networks launching their North American base of operation in St. Louis and we couldn’t be more pleased.”

METOS UK virtual weather station offers accuracy without the hardware

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Agri-TechE

METOS UK will be showcasing its virtual weather station at LAMMA on 4-5 May in Birmingham, which offers simple, cost-effective weather forecasts and in-field weather conditions with no maintenance costs and no hardware. Plus, root crop growers can take a look at new sensor for monitoring storage environment conditions for potatoes, carrots and onions crops, and an in-field yield estimator app for potato crops.

 

LAMMA visitors will be able to get free weather forecasts for a month by signing up on the day or collecting a discount code from the METOS stand. The Virtual Weather station gives users access to all the tools in METOS UK’s digital platform, FIeldClimate, and seamless integration with third party software such as the John Deere Operation Centre,

 

The virtual weather station can be used anywhere on earth, fixed at one coordinate, and offers the same range of solutions as a physical weather station. It calculates all the essential parameters to support daily decision

making on-farm, and can help with work planning. Disease models are available as an added option.

 

For root crop growers, METOS UK’s blue tuber-shaped SolAntenna contains sensors to measure and

track temperature, humidity, and CO2 levels in-store. Suitable for use in potato, onion, carrot and other stored root crops, the live data from the sensors enables storage conditions to be assessed in real-time, with preventative action taken to prevent rots and quality deterioration.

 

In the field, METOS UK’s SolGrader app will calculate the estimated tuber size distribution, overall crop weight, yield, and value of a potato crop, from a photo taken of tubers on a special blue mat.

 

METOS UK can be found at LAMMA in Hall 1, stand 11.140.

Report from Groundswell 2022 – regenerative farming on the rise

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Agri-TechE
The views expressed in this Member News article are the author's own and do not necessarily represent those of Agri-TechE.

Reporting by Holdsworth Associates.

‘The FSA investigates food fraud – will there be an equivalent for fraud in carbon goods?’ asked the Food Tsar Henry Dimbleby at Groundswell 2022.

Speaking at the event, Defra Secretary of State George Eustice warned that farmers need to be careful before committing to carbon payment schemes. He advised that it was an embryonic market and farmers would be wise to seek legal advice before jumping on to a scheme, particularly around the exit strategy in case there was a need to renegotiate.

He was speaking in response to questions from the floor about how the market in carbon will be regulated and if indeed it will provide an additional income stream for farmers.

The Secretary of State agreed that it needed regulation and went on to explain that the Treasury was currently developing a ‘Green Taxonomy’, led by Richard Benyon, to create a common framework for investments that can be defined as environmentally sustainable and clarify what impact interventions have.

Support for sustainable farming

The minister stressed government support for a move towards more regenerative agriculture and announced that farmers would be able to apply for the Sustainable Farming Incentive from 30th June and that it would be a rolling programme, with no deadlines for entering or submitting paperwork. First payments would come three months after enrolment followed by quarterly payments.

Farmer Ian Davis, who is an advocate of regenerative farming, talked from experience when he said the transition to regenerative farming is risky for businesses, explaining that a period is needed where a drop in output allows nature recovery. He said he was struggling to see how this transition was being supported: “Regenerative farming is not prescriptive; you can follow the instructions to the letter without delivering the benefits,” he warned. “It’s more about the mindset, not just the practices – the ‘why’ not the ‘how’.”

Ian would like to see support for peer-to-peer learning, with those with muddy boots who have practiced regenerative farming providing the advice, and greater financial support during the transitional period to replace loss of income.

Land use management core to strategy

George Eustice was challenged on the decision to drop consumer-facing elements of the National Food Strategy proposed by Henry Dimbleby, such as reducing meat and dairy consumption by 30% and the sugar tax. The plan had taken a systems approach identifying key issues at the heart of food system, but this also meant it cut across many government departments, including health, with the buck stopping at the Treasury.

It was clear from the discussion that the Defra response was restricted to the elements of the Food Plan where it had autonomy, focussing on the transition to a more regenerative approach to farming and investment in technologies to mitigate environmental impacts.

Core to the government strategy is land use management. The SoS gave the statistics that the majority of food production was on a small part of farmed land, that there were opportunities to make space for the nature both through the way the land was cultivated and by increasing hedgerows and changes to land use on marginal land.

Eustice explained that a healthy farmed ecosystem does need the inclusion of some livestock in a lowland rotation for soil health and well managed pasture can be part of the solution.

“If the UK can make and share technological solutions with the rest of the world this can create global change.” He cited a number of projects that he had observed recently around the use of methane as a biofuel for adapted New Holland tractors; the development of feed additives that reduce the emissions; adoption of pasture-based systems for livestock rearing that reduce requirements for supplementary feed; and the opportunities for ‘off-land’ food production such as vertical farming.

“Adoption of a more regenerative approach to agriculture could be a model for the world,” he asserted. “We see the opportunity for sustainable agriculture and profitable food production.”

Accelerating Adoption fund delayed

Concerns were raised from the floor about delays in the ‘Accelerating Adoption’ fund which is aimed specifically at farmer-led innovation.

The fund aims to provide facilitation and funding for farmers and growers to connect with each other, as well as with researchers and businesses, to trial innovative technologies, processes and practices on-farm.

The Secretary of State addressed this and confirmed that the fund had been delayed as the department focussed on the Sustainable Farming Incentive (SFI), which opens for farmer enrolment on June 30th 2022.

Food pricing ‘elephant in the room’

Minette Batters, the NFU president, had promised at the outset to be on her best behaviour. She stressed the benefit of working with an agricultural minister that understood farming.

She commented that what was needed was a new economic model for farming – focussed not just on carbon but also reward for clean water and biodiversity – but that food pricing is the ‘elephant in the room’ that nobody is allowed to talk about.

She also stressed that the food strategy needed cross-party support, as farming and the environment needs long term approach.

She urged the minister to listen to the wisdom coming from the audience at Groundswell particularly around a soil first approach, which is the ‘answer to global warming and global feeding’.

And then she called to the community to lean in – “let’s do it, let’s work together”.

Exciting research on plant infections awarded a multi-million euro grant

Member News
The views expressed in this Member News article are the author's own and do not necessarily represent those of Agri-TechE.


The Sainsbury Laboratory have announced that their Executive Director, Prof. Nick Talbot FRS, and his research group were awarded a prestigious Advanced Grant of up to €2.5 million by the European Research Council (ERC).

This generous grant will allow the Talbot group to provide fundamental new insight into how valuable cereal crops are infected by the devastating blast fungus.

The ERC is the premier European funding organisation for excellent frontier research as part of the Horizon Europe programme and only 14.6% of the submitted proposals were successful.

Why do we need to understand more about the blast fungus?

Each year, the rice blast fungus Magnaporthe oryzae destroys enough rice to feed 60 million people. In addition, the fungus causes a newly emerging disease of wheat that now threatens wheat production in Bangladesh and sub-Saharan Africa.

Many of the world’s most serious plant diseases are caused by filamentous fungi such as M. oryzae. Annually, plant diseases claim up to 40% of the total world harvest and their control is vital to the development of sustainable agriculture.

This is particularly important in face of the climate emergency, as we need to quickly reduce the environmental impacts of our agricultural systems whilst providing more healthy food for a growing human population.

The Talbot group are renowned for scientific discoveries which have led to new insights into how fungal pathogens evolved the capacity to cause some of the worlds’ most important crop diseases, many of which target staple cereals such as rice and wheat.

Nick Talbot’s research group has also made contributions in the application of molecular genetics to study how fungi cause diseases. Because plant pathogenic fungi are so difficult to analyse experimentally, we know relatively little about the infection mechanisms of many of the world’s most serious cereal pathogens.

How does the blast fungus infect plants?

Magnaporthe oryzae shares an important feature with many other plant pathogens – such as rusts and powdery mildews – which allows them to infect their hosts. These pathogens use specialized cells called appressoria which generate immense pressure to breach the tough outer layer of plants (up to 40 times the pressure of a car tyre). This is one of the reasons why M. oryzae has become an important model organism for investigating the biology of plant disease.

The ambitious SEPBLAST project proposed by the Talbot group will draw upon their recent discoveries which have shown that fungal morphogenetic proteins, called septins, are essential for rice blast disease. Septins are pivotal to the function of appressoria as well as transpressoria (which are the infection cells of M. oryzae that invade host cells once inside the plant). Septins are key determinants of virulence but are still poorly understood in this context.

This project will lead to a completely new level of understanding of the role of septins in plant disease and will facilitate intervention strategies against many diseases that plague the world’s crops.

To secure future food supplies we need new and durable methods of disease resistance, either by deploying the immune systems of plants or devising new methods to prevent plant infection by micro-organisms.

Nick Talbot says, “I am delighted and honoured to win an ERC grant supporting high-risk high-reward science, to which we are strongly committed at TSL. We are very excited to learn more about the role of the remarkable septins during rice blast disease.”

President of the ERC, Prof. Maria Leptin congratulated the awardees from 21 EU Member States and associated countries, “By following their scientific curiosity, these senior researchers are pushing the frontiers of our knowledge in a wide range of fields.”

This article was originally posted by our partner, The Sainsbury Laboratory. You can check our their website here!

Overcoming the Challenges of Clostridial Engineering with CLEAVE™ technology

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The views expressed in this Member News article are the author's own and do not necessarily represent those of Agri-TechE.

Non-pathogenic clostridia have promising utility for many different applications. This includes their use for recombinantly producing proteins that have historically been difficult to express, such as malarial proteins and other protozoal targets. However, researchers have long struggled to leverage these benefits, largely due to a lack of effective tools for manipulating the clostridial genome. CLEAVE™ technology overcomes the inherent challenges of clostridial engineering and has been cited in several publications for generating recombinant clostridial strains.

Why are researchers keen to exploit non-pathogenic clostridia?

A main reason for researchers’ interest in non-pathogenic clostridia stems from the fact that its use as a recombinant protein expression host offers several advantages over existing systems. Not only does clostridia have a rapid doubling time and simple growth media requirements, but it also has the ability to release protein products directly into the fermentation media, or in association with the spore complex, thereby avoiding potential host-toxicity issues. Additionally, because clostridia is Gram positive, using it for recombinant protein production eliminates the need for an endotoxin removal step, translating to higher product yields and reduced downstream processing costs.

How is CLEAVE™ used for manipulating the clostridial genome?

CLEAVE™ is a patented technology based on the endogenous CRISPR-Cas system, an adaptive bacterial and archaeal defense mechanism that functions by cleaving foreign DNA. Unlike other CRISPR-Cas technologies, which use non-endogenous expression of nucleases such as cas9, CLEAVE™ ensures high selection efficiency with no impact on cell growth, resulting in engineered strains free of undesired plasmids and antibiotic resistance markers. The CLEAVE™ approach also provides greater flexibility in target selection. Using CLEAVE™, researchers have been able to produce a broad range of gene edits, including in-frame deletions, single nucleotide polymorphisms (SNPs), new DNA insertions, and multiple targeted knockouts, all without introducing unwanted mutations into the clostridial genome.

Proven utility of CLEAVE™

While CLEAVE™ enables researchers to produce any desired genetic change in clostridia, its published applications to date have largely focused on manipulating solvent metabolism. Importantly, using clostridia for solvent production represents a more sustainable approach than established oil-derived chemical processes and promises to pave the way towards further industrial applications.

In their 2019 publication, Atmadjaja et al. used CLEAVE™ to manipulate the genome of the solventogenic clostridial species C. saccharoperbutylacetonicum N1-4(HMT), targeting the spo0A gene, which impacts on the microbe’s ability to sporulate1. Their data showed CLEAVE™ to be capable of producing SNPs, in-frame deletions, and DNA integration – something that was not previously possible with a single method. Subsequent studies (unpublished) have proven CLEAVE™ to support the synthesis of new products, ranging from primary metabolites to complex recombinant proteins.

Another study using C. saccharoperbutylacetonicum N1-4(HMT) for targeted gene editing with CLEAVE™ created a deletion in the gene gapN, which controls the cellular transition from acid to solvent synthesis2. Here, Monaghan et al. showed this strategy to expedite the switch to solventogenesis, suggesting it to be a viable approach to increase solvent production. Critically, the engineered strain exhibited no unexpected mutations, proving CLEAVE™ to circumvent the risk of off-target effects.

Most recently, CLEAVE™ was used to generate knock outs in several key genes required for solvent and acid synthesis3. By doing this, Baur et al. were able to convert C. saccharoperbutylacetonicum N1-4(HMT) into a butyrate producer, highlighting the utility of CLEAVE™ for multi-gene targeting.

To discuss how CLEAVE™ could benefit your research, contact us today!

References

  1. Atmadjaja, AN, et al. CRISPR-Cas, a highly effective tool for genome editing in Clostridium saccharoperbutylacetonicum N1-4(HMT), FEMS Microbiology Letters, 366, 2019, fnz059. doi:10.1093/femsle/fnz059
  2. Monaghan TI, et al. Deletion of glyceraldehyde-3-phosphate dehydrogenase (gapN) in Clostridium saccharoperbutylacetonicum N1-4(HMT) using CLEAVE™ increases the ATP pool and accelerates solvent production, Microb Biotechnol. 2021 Dec 19. doi: 10.1111/1751-7915.13990.
  3. Baur ST, et al. Increased Butyrate Production in Clostridium saccharoperbutylacetonicum from Lignocellulose-Derived Sugars, Appl Environ Microbiol. 2022; e0241921. doi:10.1128/aem.02419-21.