Senior Metabolomics Bioinformatician

About the Job

We have an exciting opportunity for an experienced Senior Metabolomics Bioinformatician to join the Metabolomics Data Analysis Team of Research Predictive Science in Product Safety. In this role you will play a vital role in supporting the R&D projects with metabolomics driven insights, contributing to cutting-edge research within our dynamic team. Key responsibilities will include:

• Supporting multiple projects simultaneously, balancing tight deadlines with rigorous scientific standards.
• Performing metabolomics data processing and data analysis across diverse use cases, primarily focused on understanding the behaviour of chemical or biological solutions for addressing agricultural challenges.
• Designing and executing novel approaches to maximise the output from metabolomics datasets (advanced statistical modelling, machine learning and AI applications, novel data mining and visualisation techniques, biological context integration etc).
• Performing high quality, insightful data interpretation to address critical project challenges.
• Designing and optimising data handling and retrieval solutions, while representing metabolomics in digital infrastructure projects.
• Serving as the metabolomics subject matter expert in multidisciplinary projects, including multi-omics integration.
• Representing the Syngenta Metabolomics Platform capabilities in internal and external scientific communities.

About You

• PhD or equivalent extensive experience in bioinformatics, metabolomics, chemistry, biology, data science, or related field.
• In-depth metabolomics data processing / bioinformatics experience:
  • Processing of targeted and untargeted high-resolution LC-MS metabolomics data using specialist software (vendor or open source).
  • Good understanding of mass spectrometry and metabolomics data architectures.
  • Good understanding of the impact of sample preparation, quality control procedures and analytical chemistry on data processing requirements and correction tools.
  • Peak picking, peak annotation, data normalisation and filtering techniques.
  • Bioinformatics and pipeline development skills in e.g., KNIME, R or Python.
  • Data handling expertise, database and literature searching.
• Experience in multivariate statistics and downstream data analysis approaches:  differentially abundant metabolite (DAMs) selection, pathway analysis, biochemical data interpretation.
• Exceptional attention to detail, compliance with best practices and quality assurance processes.
• Ability to present complex results to non-specialists in a clear and concise manner.
• Strong adaptability with proven ability to rapidly acquire new skills, combined with a collaborative mindset.

Desirable skills/experience:

• Toxicology metabolomics experience, familiarity with or contribution to regulatory NAMs use cases, relevant OECD guidance documents and reporting frameworks.
• Ability to deliver technical leadership in defined areas.
• Experience with multiple application areas of metabolomics (in vitro, plant, environmental, mammalian, human etc).
• Multi-omics data integration.
• Experience with Thermo Orbitrap MS and softwares like Xcalibur, Freestyle, Tracefinder, Compound Discoverer, LipidSearch.

About Us

Syngenta Crop Protection is a leader in agricultural innovation, bringing breakthrough technologies and solutions that enable farmers to grow productively and sustainably. We offer a leading portfolio of crop protection solutions for plant and soil health, as well as digital solutions that transform the decision-making capabilities of farmers. Our 17,900 employees serve to advance agriculture in more than 90 countries around the world. Syngenta Crop Protection is headquartered in Basel, Switzerland, and is part of the Syngenta Group.

Our employees reflect the diversity of our customers, the markets where we operate and the communities which we serve. No matter what your position, you will have a vital role in safely feeding the world and taking care of our planet. Join us and help shape the future of agriculture!