PBD Biotech

PBD Biotech has developed a rapid diagnostic that detects and identifies mycobacteria causing bovine TB and Johne’s disease from a single sample of blood.

Actiphage, a novel phage-based technology, is able to sensitively detect the presence of live bacteria in blood or milk. It offers early stage detection of both bTB and Johne’s Disease before the carrier becomes infective, enabling for the first time preventative management of these economically damaging diseases.

Unlike the existing gold-standard skin test for bovine TB which measures the immune response of the animal, Actiphage test directly identifies the presence of live bacteria and so can be used to distinguish vaccinated from unvaccinated animals.

Actiphage can also be used as a milk test for quality assurance of dairy products.

Actiphage has been successfully used to detect live mycobateria in raw milk, pasteurised milk, powdered infant formula, cheese and in the blood of infected animals. The highly sensitive and specific test has been applied to samples from 17 species so far, including cattle, camelids and exotic animals.

PBD Biotech has raised funding for trials to take Actiphage for international validation by the World Organisation for Animal Health (OIE). The test has been approved for use in England and Wales by the Animal & Plant Health Agency (APHA) for exceptional private use in areas of chronic TB breakdowns. Other international trials are underway

Member's Area/s of Interest

Technology

Being members of Agri-TechE is a massive asset for a start-up company in this sector and created a hugely valuable impact for our company.

Joining Agri-TechE opened numerous doors to local investors including the Eastern Agri-Tech Growth Fund and introduced us to a network of relevant bodies including the NFU and regulatory advisors with a common interest in the improved control of mycobacterial disease in agriculture.

Moreover, the opportunity to present at networking events such as REAP allowed us to really maximise PR opportunities that have had a startling impact on an early phase business.

Dr Berwyn Clarke, former CEO

Is there Johne’s Disease in the herd? New rapid testing service provides yes/no answer

Is there Johne’s Disease in the herd? The answer to this question is what every dairy farmer and milk processor wants to know. Now a new rapid testing service from PBD Biotech will enable them to find out in days if a bulk milk or blood sample contains Mycobacterium avium subspecies paratuberculosis (MAP), the bacteria that causes this economically devastating disease.

Novel Phage technology attracts top scientist to PBD Biotech

“PBD Biotech has developed an exciting and potentially disruptive technology that uses bacteriophage to improve the molecular diagnosis of tuberculosis – I’m not aware of any comparable approaches that are commercially available at the moment,” says Dr Tomas Richardson, a specialist in DNA replication and molecular diagnostics, who is joining the company to set up a dedicated R&D laboratory and head up the research team...

Jane Theaker appointed as new CEO as PBD Biotech gears up for next phase of development

PBD Biotech, is moving to the next stage of its development. It has appointed Jane Theaker, of precision medicine company Kinomica, as the new CEO and brings Jonnie Yewdall, into a full-time role as Commercial Director

Arden Farms first to test deer for Johne’s Disease using Actiphage

Arden Farms are the first to use the Actiphage blood test to test their herd of Red Deer for Johne’s Disease. The wasting condition is difficult to detect as it can lay dormant in the animal for many years until it is triggered by stress.

Heartbreak & Hope the fight against bovine TB

Jonnie Yewdall, a former dairy farmer, has been appointed Commercial Director at PBD Biotech. The company recently gained funding to take its Actiphage® blood test for bovine TB (bTB) and Johne’s Disease through the validation required for international industry acceptance. Jonnie will be talking about his experiences and development of the Actiphage test at the Agri-TechE event ‘Heartbreak and hope – the story of a new diagnostic for bovine TB’ 6th July

PBD Biotech secures £2.3m funding for OIE validation of its rapid, accurate bovine TB test

PBD Biotech has secured a £2.3m investment to take Actiphage through to validation by the World Organisation for Animal Health (OIE). Full validation will enable international adoption of this novel, patented, diagnostic for mycobacterial diseases, which include human tuberculosis and Johne’s Disease.

Top innovation award for Actiphage, rapid tuberculosis test

Actiphage®, a rapid, accurate test for tuberculosis that detects the presence of the live mycobacteria in a sample of blood or milk, has been awarded the Innovation Award 2021 by the British Veterinary Association (BVA).

PBD Biotech’s rapid new Actiphage test for human and animal diseases progresses in Canada

Johne’s disease costs the Canadian dairy industry an estimated $90 million a year through loss of production. Now, advisory services and funding from NRC IRAP is enabling PBD Biotech to further research and progress development of its unique Actiphage® diagnostic for hard-to-detect mycobacterial diseases, such as Johne’s.

As bovine TB reaches record levels in Wales permission is given for first trial of PBD Biotech’s Actiphage® blood test

Vet Robert Price-Jones comments in a BBC interview that the blood test Actiphage offers the potential for eradicating bovine TB from the farm: “Early identification of animals at risk of bovine TB enables effective disease management and control.”

PBD Biotech

Member's Area/s of Interest

Is there Johne’s Disease in the herd? New rapid testing service provides yes/no answer

Novel Phage technology attracts top scientist to PBD Biotech

Jane Theaker appointed as new CEO as PBD Biotech gears up for next phase of development

PBD Biotech, is moving to the next stage of its development. It has appointed Jane Theaker, of precision medicine company Kinomica, as the new CEO and brings Jonnie Yewdall, into a full-time role as Commercial Director

Arden Farms first to test deer for Johne’s Disease using Actiphage

Arden Farms are the first to use the Actiphage blood test to test their herd of Red Deer for Johne’s Disease. The wasting condition is difficult to detect as it can lay dormant in the animal for many years until it is triggered by stress.

Heartbreak & Hope the fight against bovine TB

PBD Biotech secures £2.3m funding for OIE validation of its rapid, accurate bovine TB test

Top innovation award for Actiphage, rapid tuberculosis test

Actiphage®, a rapid, accurate test for tuberculosis that detects the presence of the live mycobacteria in a sample of blood or milk, has been awarded the Innovation Award 2021 by the British Veterinary Association (BVA).

PBD Biotech’s rapid new Actiphage test for human and animal diseases progresses in Canada

As bovine TB reaches record levels in Wales permission is given for first trial of PBD Biotech’s Actiphage® blood test

Vet Robert Price-Jones comments in a BBC interview that the blood test Actiphage offers the potential for eradicating bovine TB from the farm: “Early identification of animals at risk of bovine TB enables effective disease management and control.”

Actiphage test wins UK Royal Dairy Innovation Award 2019

PBD Biotech’s Actiphage technology wins Royal Dairy Innovation Award 2019

Interest in Actiphage diagnostic from world leading milk industry

PBD Biotech takes test for animal and public health to India in UK Government trade delegation.

PBD Biotech secures grant of key patent for new bacterial diagnostic technology

Actiphage, the novel diagnostic technology developed by PBD Biotech, has secured its unique IP from the European Patent Office

APHA grants access to new Actiphage technology for chronic TB breakdowns

UK Government publishes protocol permitting 'exceptional private use' of Actiphage 6-hour test on TB stricken herds in England

New research explains MAP found in pasteurised milk

New research shows phage-based test is able to rapidly identify low levels of live mycobacteria in pasteurised milk

Revolutionising livestock disease management

Considering new testing for Bovine TB.

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